Hantavirus

Data on hantavirus discussed by W. Handke and colleagues

Published in Medical Letter on the CDC and FDA, May 3rd, 2009

"Immediately after viral infection, innate responses including expression of IFN-alpha/beta and IFN-stimulated genes (ISGs) are elicited ubiquitously by recruitment of specific pathogen recognition receptors. The velocity to induce FFN-alpha/beta and ISGS in response to an infection is often decisive for virulence," investigators in Berlin, Germany report.

"Interestingly, in primary endothelial cells ISGs are induced later by hantaviruses pathogenic to humans than those considered to be nonpathogenic or of low virulence. Here we demonstrate that pathogenic Hantaan (HTNV) and putatively nonpathogenic Prospect Hill hantavirus (PHV) differentially activate innate responses...

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Source: Medical Letter on the CDC and FDA (2009-05-03)

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