Life Sciences
Researchers from Emory University report on findings in life sciences
Published in Medical Letter on the CDC and FDA, May 10th, 2009
According to recent research from the United States, "Nearly 35 years after its discovery and 11 years after FDA approval of paclitaxel (PTX) as a breakthrough anticancer drug, the 3-D structure of the agent bound to its beta-tubulin target was proposed to be T-Taxol. The latter bioactive form has recently been challenged by the Ojima group with a structure, ''PTX-NY'' (''REDOR Taxol''), in which the C-13 side chain is proposed to adopt a different conformation and an alternative hydrogen-bonding pattern in the tubulin binding site."
"Previously, the two conformers were compared to show that only T-Taxol fits the PTX-derived electron crystallographic density. That work...
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