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West Nile Virus

Researchers from University of Texas detail new studies and findings in the area of west nile virus

Published in Medical Letter on the CDC and FDA, August 9th, 2009

"Previous studies have established the therapeutic efficacy of humanized E16 (hE16) monoclonal antibody against West Nile virus in animals," scientists in the United States report.

"Here, we assess the potential for West Nile virus strains encoding mutations in the hE16 epitope to resist passive immunotherapy and for the selection of neutralization escape variants during hE16 treatment. Resistance to hE16 in vivo was less common than expected, because several mutations that affected neutralization in vitro did not significantly affect protection in mice," wrote S.L. Zhang and colleagues, University of Texas.

The researchers concluded: "Moreover, the...

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