Published in Medical Letter on the CDC and FDA, August 9th, 2009
"Here, we assess the potential for West Nile virus strains encoding mutations in the hE16 epitope to resist passive immunotherapy and for the selection of neutralization escape variants during hE16 treatment. Resistance to hE16 in vivo was less common than expected, because several mutations that affected neutralization in vitro did not significantly affect protection in mice," wrote S.L. Zhang and colleagues, University of Texas.
The researchers concluded: "Moreover, the...
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