Cancer
Data from A. Kazi and colleagues advance knowledge in cancer
Published in Medical Letter on the CDC and FDA, August 23rd, 2009
According to a study from the United States, "Numerous proteins controlling cell cycle progression, apoptosis and angiogenesis are degraded by the ubiquitin/proteasome system, which has become the subject for intense investigations for cancer therapeutics. Therefore, we used in silico and experimental approaches to screen compounds from the NCI chemical libraries for inhibitors against the chymotrypsin-like (CT-L) activity of the proteasome and discovered PI-083."
"Molecular docking indicates that PI-083 interacts with the Thr21, Gly47 and Ala49 residues of the beta 5 subunit and Asp114 of the beta 6 subunit of the proteasome. PI-083 inhibits CT-L activity and cell...
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