Anthrax

Report summarizes anthrax study findings from M.Y. Zakharova and co-researchers

Published in Medical Letter on the CDC and FDA, September 13th, 2009

According to recent research published in the Journal of Biological Chemistry, "Lethal factor (LF), a zinc-dependent protease of high specificity produced by Bacillus anthracis, is the effector component of the binary toxin that causes death in anthrax. New therapeutics targeting the toxin are required to reduce systemic anthrax-related fatalities."

"In particular, new insights into the LF catalytic mechanism will be useful for the development of LF inhibitors. We evaluated the minimal length required for formation of bona fide LF substrates using substrate phage display. Phage-based selection yielded a substrate that is cleaved seven times more efficiently by LF...

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Source: Medical Letter on the CDC and FDA (2009-09-13)

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