Bioluminescence

New bioluminescence study findings recently were reported by Y.M. Zhang and co-researchers

Published in Medical Letter on the CDC and FDA, September 20th, 2009

According to recent research published in the journal Cancer Research, "ABCG2 is a member of the ATP-binding cassette (ABC) family of transporters, the overexpression of which is associated with tumor resistance to a variety of chemotherapeutic agents. Accordingly, combining ABCG2 inhibitor(s) with chemotherapy has the potential to improve treatment outcome."

"To search for clinically useful ABCG2 inhibitors, a bioluminescence imaging (BLI)-based assay was developed to allow high-throughput compound screening. This assay exploits our finding that D-luciferin, the substrate of firefly luciferase (fLuc), is a specific substrate of ABCG2, and ABCG2 inhibitors block...

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Source: Medical Letter on the CDC and FDA (2009-09-20)

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