Escherichia Coli

New data from University of Guelph illuminate research in Escherichia coli

Published in Medical Letter on the CDC and FDA, October 11th, 2009

"O island 48 (OI-48) of Escherichia coli consists of three functional gene clusters that encode urease, tellurite resistance (Te-r), and putative adhesins Iha and AIDA-1. The functions of these clusters in enterohemorrhagic E. coli (EHEC) O157:H7 infection are unknown," scientists in Guelph, Canada report.

"Deletion mutants for these three regions were constructed and evaluated for their ability to adhere to epithelial cells in vitro and in ligated pig ileal loops. Deletion of the Te-r gene cluster reduced the ability of the organism to adhere to and form large clusters on IPEC-J2 and HEp-2 cells. Complementation of the mutation by introducing the wild-type ter genes...

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Source: Medical Letter on the CDC and FDA (2009-10-11)

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