Published in Medical Letter on the CDC and FDA, October 25th, 2009
"The spike glycoprotein (GP) is believed to be one of the major determinants of virus pathogenicity. In this study, we demonstrated the molecular mechanism responsible for the downregulation of surface markers caused by EBOV GP expression," wrote O. Reynard and colleagues, INSERM.
The researchers concluded: "We showed that expression of mature GP on the plasma membrane results in the masking of cellular surface proteins, including major histocompatibility complex class I. Overexpression of GP also results in the...
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