Legionnaire Disease

Research from Tufts University in legionnaire disease provides new insights

Published in Medical Letter on the CDC and FDA, November 29th, 2009

According to recent research from the United States, "The amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. pneumophila intracellular replication."

"Inactivation of dupA resulted in depressed L. pneumophila growth and sustained hyperphosphorylation of the amoebal MAP kinase ERK1, consistent with loss of a phosphatase activity. Bacterial challenge of wild-type amoebae induced dupA expression and resulted in transiently increased ERK1 phosphorylation, suggesting that dupA and ERK1...

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Source: Medical Letter on the CDC and FDA (2009-11-29)

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