Published in Medical Letter on the CDC and FDA, December 20th, 2009
"Currently, there are no drug candidates or even tool compounds that modulate Wnt-mediated receptor trafficking, and subsequent Writ signaling. We examined libraries of FDA-approved drugs for their utility as Frizzled internalization modulators, employing a primary imaged-based GFP fluorescence assay that uses Frizzled I endocytosis as the readout. We now report that...
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