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Anthrax

Research on anthrax discussed by scientists at University of Toronto

Published in Medical Letter on the CDC and FDA, December 27th, 2009

According to recent research published in the journal Biochemistry, "The protective antigen component of anthrax toxin binds the I domain of the anthrax toxin receptors. ANTXR1 and ANTXR2, in it manner akin to how integrins bind their ligands."

"The I domains of integrins and ANTXR1 both have high- and low-affinity conformations. and the cytosolic tails of these receptors associate with the actin cytoskeleton I-lie association of ANTXR1 with the cytoskeleton correlates with weakened binding to PA, although it mechanistic explanation for this observation is lacking. Here, we identified a segment in the cytoplasmic tail of ANTXR1 required for its association with...

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