Stem Cell Research

New stem cell research data have been reported by A.F. Cashen and co-authors

Published in Medical Letter on the CDC and FDA, January 3rd, 2010

"Plerixafor is a novel small molecule that inhibits CXCR4 binding to SDF-1, on interaction that is a principal regulator of hematopoietic stem cell trafficking. Phase I studies demonstrated that a single plerixafor hydrochloride dose results in a marked increase in white blood cell count and circulating CD34(+) stem cells," researchers in the United States report.

"Subsequent single-arm and randomized clinical trials hove established the efficacy of plerixafor for autologous stem cell mobilization, both combined with granulocyte colony-stimulating factor (C-CSF) and as a single agent. In December 2008 the FDA approved plerixafor in combination with G-CSF for autologous...

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Source: Medical Letter on the CDC and FDA (2010-01-03)

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