West Nile Virus

Researchers from University of Michigan report on findings in west nile virus

Published in Medical Letter on the CDC and FDA, January 24th, 2010

According to recent research from the United States, "Neuroinvasive West Nile virus (WNV) infections may cause acute flaccid paralysis (AFP); in fatal cases, anterior horn cell loss is presumed to be caused by direct viral infection. In related animal models, however, glutamate excitotoxicity mediates bystander injury of uninfected anterior horn cells, suggesting additional pathogenic mechanisms."

"We examined expression of the principal excitatory amino acid transporter (EAAT) of astrocytes (i.e. EAAT-2 in humans, glutamate transporter 1 in hamsters) in the spinal cord of human WNV-induced AFP patients and in hamsters with WNV-induced AFP by immunohistochemistry. Glial...

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Source: Medical Letter on the CDC and FDA (2010-01-24)

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