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Hantavirus

Scientists at University of Helsinki detail research in hantavirus

Published in Medical Letter on the CDC and FDA, January 31st, 2010

According to recent research from Helsinki, Finland, "The cytoplasmic tails of envelope glycoprotein Gn of pathogenic hantaviruses but not of the apathogenic Prospect Hill virus (PHV) were recently reported to be proteasomally degraded in simian COS7 cells."

"Here, we show that the cytoplasmic tails of the glycoproteins of the apathogenic hantaviruses Tula virus (TULV) and PHV are also degraded through the ubiquitin-proteasome pathway, both in human HEK-293 and in simian Vero E6 cells. TULV Gn tails formed aggresomes in cells with proteasomal inhibitors," wrote H. Wang and colleagues, University of Helsinki.

The researchers concluded: "Degradation...

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