Chromosome Aberration
Study data from M.L. Homiski and co-authors update knowledge of chromosome aberration
Published in Medical Letter on the CDC and FDA, March 28th, 2010
According to recent research published in the journal Environmental and Molecular Mutagenesis, "The in vitro micronucleus assay is under consideration by regulatory agencies as a suitable alternative to the in vitro chromosome aberration (CA) assay. At Pfizer, we utilized a non-Good Laboratory practices cytokinesis-block in vitro micronucleus (CBMN) assay in CHO cells as a screen to predict the regulatory outcome of the human lymphocyte CA assay, and we have retrospectively analyzed a highly select set of 112 internal drug candidates to measure concordance."
"Overall, our exploratory CBMN correctly classified 97 of 112 (86.6%) compounds in the CA assay....
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