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Experimental Autoimmune Uveoretinitis

Research from Hokkaido University provides new data on experimental autoimmune uveoretinitis

Published in Medical Letter on the CDC and FDA, May 16th, 2010

New research, 'Amelioration of experimental autoimmune uveoretinitis with nuclear factor-{kappa}B Inhibitor dehydroxy methyl epoxyquinomicin in mice,' is the subject of a report. "Experimental autoimmune uveoretinitis (EAU), a Th1/Th17 cell-mediated autoimmune disease induced in mice, serves as a model of human endogenous uveitis. In this model, proinflammatory cytokines and various stimuli activate the transcriptional factor, nuclear factor-kappaB (NF-kappaB), in the retina," scientists in Sapporo, Japan report.

"The therapeutic effect of the NF-kappaB inhibitor, dehydroxy methyl epoxyquinomicin (DHMEQ), was examined on EAU. EAU was induced in B10.BR mice by K2 peptide...

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