Nanobodies
Research from Katholieke Universiteit Leuven, Rega Institute for Medical Research in the area of nanobodies described
Published in Medical Letter on the CDC and FDA, August 8th, 2010
New investigation results, 'An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production,' are detailed in a study published in Journal of Biological Chemistry. "The human immunodeficiency virus, type 1 (HIV-1)-encoded Rev protein is essential for the expression of late viral mRNAs. Rev forms a large organized multimeric protein-protein complex on the Rev response element of these viral mRNA species and transports them from the nucleus to the cytoplasm, exploiting the CRM1-mediated cellular machinery," scientists writing in the Journal of Biological Chemistry report.
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