Sickle Cell Anemia
Compound may prevent sickle cell pain crises
Published in Medical Letter on the CDC and FDA, February 20th, 2011
The aptamer, developed by Archemix Corporation in Cambridge, Mass., appears to work by occupying sticky receptors lining the walls of small blood vessels where sickle-shaped red blood cells and white blood cells can pile up, according to the study published in Blood. The cell traffic jam occludes blood and oxygen flow, causing pain, organ damage and, eventually, death.
"Many...
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