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Vaccines

New Vaccines Findings from Y.C. Liao and Co-Researchers Published

Published in Medical Letter on the CDC and FDA, February 27th, 2011

2011 FEB 27 -- "The HA1 domain of influenza A viruses is critical for immune escape and host receptor recognition. However, the association between HA1 evolution and host species-specific adaptations remains unclear," scientists writing in the journal Vaccine report.

"We have identified the amino acid sites that are related to the host species-specific adaptations by systematically comparing the evolutionary dynamics of HA1 between human and avian hosts for both H1N1 and H3N2 viruses. We can thus refine the ''positively selected sites'' in the HA1 domain of these two virus subtypes to those that occur only in humans. We further demonstrate that the...

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