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Genetics and Plague

New Findings from University of Michigan in the Area of Genetics and Plague Published

Published in Medical Letter on the CDC and FDA, May 8th, 2011

2011 MAY 8 -- Scientists discuss in 'Contributions of chaperone/usher systems to cell binding, biofilm formation and Yersinia pestis virulence' new findings in Genetics and Plague. "Yersinia pestis genome sequencing projects have revealed six intact uncharacterized chaperone/usher systems with the potential to play roles in plague pathogenesis. We cloned each locus and expressed them in the 'fim Escherichia coli strain AAEC185 to test the assembled Y. pestis surface structures for various activities," researchers in Ann Arbor, United States report.

"Expression of each chaperone/usher locus gave rise to specific novel fibrillar structures on the...

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