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Molecular Biology

Findings from T. Warnecke and Co-Authors Provide New Insights into Molecular Biology

Published in Medical Letter on the CDC and FDA, September 4th, 2011

2011 SEP 4 -- According to the authors of a study from Paris, France, "Changes in effective population size impinge on patterns of molecular evolution. Notably, slightly deleterious mutations are more likely to drift to fixation in smaller populations, which should typically also lead to an overall acceleration in the rates of evolution."

"This prediction has been validated empirically for several endosymbiont and island taxa. Here, we first show that rate accelerations are also evident in bacterial pathogens whose recent shifts in virulence make them prime candidates for reduced effective population size: Bacillus anthracis, Bordetella parapertussis,...

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