Vaccines

Investigators at University of Groningen Publish New Data on Vaccines

Published in Medical Letter on the CDC and FDA, October 2nd, 2011

2011 OCT 2 -- According to the authors of a study from Groningen, Netherlands, "Regulatory T-cells (Treg) hamper immune responses elicited by cancer vaccines. Therefore, depletion of Treg is being used to improve the outcome of vaccinations."

"We studied whether an alphavirus vector-based immunotherapeutic vaccine changes the number and/or activity of Treg and if Treg depletion improves the efficacy of this vaccine against tumours. The vaccine is based on a Semliki Forest virus (SFV). The recombinant SFV replicon particles encode a fusion protein of E6 and E7 from human papillomavirus (HPV) type 16 (SFVeE6,7). We demonstrated that SFVeE6,7 immunization did...

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Source: Medical Letter on the CDC and FDA (2011-10-02)

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