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Molecular Microbiology

Researchers from Max Planck Institute Discuss Findings in Molecular Microbiology

Published in Medical Letter on the CDC and FDA, October 23rd, 2011

2011 OCT 23 -- According to the authors of a study from Berlin, Germany, "Malaria parasites undergo a population expansion inside the host liver before disease onset. Developmental arrest inside host hepatocytes elicits protective immune responses."

"Therefore, elucidation of the molecular mechanisms leading to mature hepatic merozoites, which initiate the pathogenic blood phase, also informs anti-malaria vaccine strategies. Using targeted gene deletion in the rodent model malaria parasite Plasmodium berghei, we show that a Plasmodium-specific Apicoplast protein plays an important role for Liver Merozoite formation (PALM). While the resulting knockout...

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