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Plague

Data on Plague Discussed by Researchers at University of Miami

Published in Medical Letter on the CDC and FDA, December 18th, 2011

2011 DEC 18 -- According to the authors of a study from Miami, Florida, "The ability of Yersinia pestis to forestall the mammalian innate immune response is a fundamental aspect of plague pathogenesis. In this study, we examined the effect of Ail, a 17-kDa outer membrane protein that protects Y. pestis against complement-mediated lysis, on bubonic plague pathogenesis in mice and rats. The Y. pestis ail mutant was attenuated for virulence in both rodent models."

"The attenuation was greater in rats than in mice, which correlates with the ability of normal rat serum, but not mouse serum, to kill ail-negative Y. pestis in vitro. Intradermal infection with the...

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