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Renal Insufficiency

Research data from Mayo Clinic, Medical Department update understanding of renal insufficiency

Published in Medical Patent Law Weekly, March 26th, 2008

Researchers in the United States conducted a study "To create a more clinically relevant model of hemodialysis graft failure in pigs by creating chronic renal insufficiency before polytetrafluoroethylene (PTFE) hemodialysis graft placement and to determine the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) at the vein-to-graft anastomosis (VGA). Chronic renal insufficiency was created in 14 castrated juvenile male pigs with complete embolization of the left renal artery and the partial embolization of the right renal artery by infusing 150-250-mu m polyvinyl acrylide spherical particles."

"The efficacy of the embolization was assessed by determining the...

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