Medical Patent Law Weekly
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Alexander Disease
Research from R. Matej and co-researchers yields new findings on Alexander disease
May 14th, 2008
"We report the first case of Alexander disease diagnosed and published in the region of former Czechoslovakia. The case was characterized by early (late infantile) onset, the absence of megacephaly but with extensive internal hydrocephaly, despite a patent aqueduct," researchers in Prague, Czech Republic report. "Neuropathology revealed severe depletion of oligodendroglia and myelin, loss of axons, prominent astrocytosis with massive intracellular, dense globular GFAP aggregates which differed from typical Rosenthal fibers. Additionally, many large aggregates of GFAP were located extracellularly. Globular GFAP aggregates were also identified in neurohypophyseal pituicytes....
Source: Medical Patent Law Weekly (2008-05-14)
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