Constipation

Research on constipation detailed by J. Thomas and co-authors

Published in Medical Verdicts and Law Weekly, July 10th, 2008

According to recent research published in the New U.K. Journal of Medicine, "Constipation is a distressing side effect of opioid treatment. As a quaternary amine, methylnaltrexone, a (mu)-opioid-receptor antagonist, has restricted ability to cross the blood-brain barrier."

"We investigated the safety and efficacy of subcutaneous methylnaltrexone for treating opioid-induced constipation in patients with advanced illness. A total of 133 patients who had received opioids for 2 or more weeks and who had received stable doses of opioids and laxatives for 3 or more days without relief of opioid-induced constipation were randomly assigned to receive subcutaneous...

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Source: Medical Verdicts and Law Weekly (2008-07-10)

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