Clostridium
Research data from J. Peppe and colleagues update understanding of clostridium
Published in Medical Verdicts and Law Weekly, July 31st, 2008
"To evaluate the safety and tolerability of a new oral solution formulation of tolevamer potassium sodium, a nonantibiotic polymer that binds Clostridium difficile toxins A and B. This phase 1 randomized, double-blind, placebo-controlled study evaluated four doses of tolevamer potassium sodium in 40 healthy volunteers using a sequential dose escalation paradigm and doses of 6, 9, 12 and 15 g day(-1) for 9 days. Within each 10 patient cohort, eight patients received active treatment and two matching placebo," investigators in the United States report.
"Placebo subjects were pooled to provide eight per arm. All subjects received three times daily dosing on days 2-8 as...
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