According to recent research from Montreal, Canada, "Caffeic acid phenethyl ester (CAPE) has recently been shown to potently stimulate glucose uptake in cultured skeletal muscle cells through the AMPK pathway and therefore to have anti-diabetic potential. We report here that CAPE increases glucose uptake in C2C12 muscle cells by 225 +/- 21%at 50 mc M, and that activation of AMPK is a consequence of the metabolic stress resulting from an uncoupling-type disruption of mitochondrial function (complete uncoupling at 50 mc M)."
"We also observe that the therapeutic potential of CAPE is offset by its high potential for toxicity. The purpose of this study was therefore to...
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