Scripps Research Institute

Inhibitors target phosphorelay signal transduction systems of microbes

Published in Medicine and Law Weekly, May 21st, 2004

Researchers discuss issues related to developing inhibitors to selectively target two-component and phosphorelay signal transduction systems of pathogenic microorganisms in a recent issue of Current Medicinal Chemistry.

According to recent research from the United States, "Two-component signal transduction systems and their expanded variants known as phosphorelays are integral elements of the virulence and antimicrobial resistance responses of a wide range of pathogenic bacteria and fungi and also regulate essential functions. As a consequence, two-component systems and phosphorelays are recognized targets for the development of novel antimicrobial agents and a...

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Source: Medicine and Law Weekly (2004-05-21)

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