Mayo Clinic

Exploiting gene mutations may combat osteoporosis and obesity

Published in Medicine and Law Weekly, September 10th, 2004

Exploitation of mutations in Toll-like receptors has the potential to combat obesity and osteoporosis Mayo Clinic researchers suggest.

"Toll receptors in Drosophila contribute to host defense and establish the body plan. Mammalian homologues of Toll, the Toll-like receptors (TLRs), are thought to function only in host defense," explained G.B. Johnson and colleagues.

In a study in mice, Johnson's team found "that mice harboring mutations in TLR4 or in CD14, a co-receptor for TLR4, have an 'ideal' body plan consisting of increased bone mineral content, density, and size as well as decreased body fat."

According to the...

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Source: Medicine and Law Weekly (2004-09-10)

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