Published in Medicine and Law Weekly, October 15th, 2004
"The features of protective murine antibodies to the Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan (GXM) have been rigorously investigated; however, the characteristics of protective human antibodies to GXM have not been defined. We produced monoclonal antibodies (MAbs) from XenoMouse mice (transgenic mice that express human immunoglobulin M [IgM], IgG2, and K), which were immunized with a C. neoformans serotype D strain 24067 GXM-diphtheria toxoid...
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