Published in Medicine and Law Weekly, October 15th, 2004
According to the report from the United States, "15-lipoxygeiiase-1 (also known as 12/15-LO in mice) and 5-LO/5-LO-activating protein (FLAP) cascades play central roles in low-density lipoprotein oxidation and leukotriene biosynthesis, respectively."
L. Zhao and C.D. Funk of the University of Pennsylvania wrote, "Several genetic and expression studies unraveling an association of the 5-LO/ FLAP pathway to human cardiovascular disease have surfaced recently. Experimental studies in 12/15-LO knockout, 15-LO-1 transgenic, and 5-LO knockout mice on atherosclerotic backgrounds...
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