Universite Paris XI

Aluminum hydroxide adjuvant induces macrophage differentiation

Published in Medicine and Law Weekly, November 5th, 2004

Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type.

"Aluminum hydroxide [Al(OH)_{3] ] ] has been used for many years as a vaccine adjuvant, but little is known about its mechanism of action. We investigated in this study the in vitro effect of aluminum hydroxide adjuvant on isolated macrophages. We showed that Al(OH)₃ -stimulated macrophages contain large and persistent intracellular crystalline inclusions, a characteristic property of muscle infiltrated macrophages described in animal models of vaccine injection, as well as in the recently described macrophagic myofasciitis (MMF) histological...}

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Source: Medicine and Law Weekly (2004-11-05)

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