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British National Institute for Medical Research

TGFbeta-related protein induces feedback regulators at poles of egg cylinder

Published in Medicine and Law Weekly, December 10th, 2004

A recent review focused on a gene network establishing polarity in the early mouse embryo.

According to the review from England, "In mammalian embryos, molecular cross-talk with extraembryonic tissues is essential to elaborate the primary body axes...[W] review a series of reciprocal interactions that occur shortly after implantation in the uterus, and discuss how they are integrated in a complex signaling network to establish antero-posterior and dorso-ventral polarity."

S.L. Ang SL and D.B. Constam of the British National Institute for Medical Research reported, "At the heart of this signaling network is the TGFbeta-related protein Nodal which acts...

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