Cell Signaling Technology Inc.

Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1

Published in Medicine and Law Weekly, January 7th, 2005

Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser¹¹⁰¹.

"Obesity and stress inhibit insulin action by activating protein kinases that enhance serine phosphorylation of IRS1 and have been thus associated to insulin resistance and the development of type 2 diabetes. The protein kinase C theta (PKC-theta) is activated by free-fatty acids, and its activity is higher in muscle from obese diabetic patients. However, a molecular link between PKC-theta and insulin resistance has not been defined yet," investigators in the United States report.

"Here we show that PKC-theta phosphorylates IRS1 at serine 1101 blocking...

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Source: Medicine and Law Weekly (2005-01-07)

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