University of Iowa
TRAF3 is important in EBV-encoded oncoprotein LMP1-mediated signaling
Published in Medicine and Law Weekly, January 14th, 2005
According to recent research from the United States, "TNFR-associated factor (TRAF)3, an adaptor protein that binds the cytoplasmic domains of both CD40 and the (LMP)1, is required for positive signaling by LMP1 but not CD40 in B lymphocytes.
"The present study further investigated how TRAF3 participates in LMP1 signaling. We found that TRAF3 mediates signaling both through direct interactions with the C-terminal activating region (CTAR)1 of LMP1 and through indirect interactions with the CTAR2 region of LMP1 in mouse B cells."
"Notably, our results...
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