Yale University
Neurogenic inflammation analyzed, role of specific action potential revealed
Published in Medicine and Law Weekly, February 4th, 2005
"Inflammatory mediators modulate voltage-gated sodium channels through protein kinase-mediated pathways. However, it is not clear whether neurogenic inflammation may also alter the properties of distantly located channels along axon shafts supplying the inflamed dermatome.
"In this study," wrote C.Y. Saab and colleagues, Yale University, "localized inflammation was induced via intradermal injection of capsaicin within the receptive field of the sural nerve, and compound action potentials (CAP) evoked by sural...
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