Brown University
Immunogenic consensus T helper epitopes for HIV vaccine engineered
Published in Medicine and Law Weekly, February 18th, 2005
According to published research from the United States, "Developing a vaccine that will stimulate broad HIV-specific T cell responses is difficult because of the variability in HIV T cell epitope sequences, which is in turn due to the high mutation rate and consequent strain diversity of HIV-1. We used a new Class II version of the EpiMatrix T cell epitope-mapping tool and Conservatrix to select highly conserved and promiscuous Class II HLA-restricted T cell epitopes from a database of 18,313 HIV-1 env sequences. Criteria for selection were: number of HIV-1 strains...
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