Southampton General Hospital, Hants

Oral lactose-ureide studied, N-15 transfers to lysine revealed

Published in Medicine and Law Weekly, March 11th, 2005

Researchers from England have reported on the transfer of a lactose component from oral lactose-ureide to lysine in normal adults.

"The metabolic fate of salvaged urea-nitrogen was explored in normal adults who had consumed a diet that provided 36 g protein/day for 7 days," wrote A.A. Jackson and colleagues, Southampton General Hospital, Hants.

"We hypothesised that the colonic microflora utilize nitrogen derived from urea salvage to synthesise lysine in functionally significant amounts for the host. Oral lactose-[(NN)-N-15-N-15]ureide is resistant to digestion but is fermented by the colonic microflora to release (NH₃ )-N-15, which can be...

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Source: Medicine and Law Weekly (2005-03-11)

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