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University of Dublin Trinity College

Semliki Forest virus vector battles fast growing murine tumors

Published in Medicine and Law Weekly, March 18th, 2005

Semliki Forest virus vector battles fast growing murine tumors.

"To assess the potential of immune stimulation in combination with apoptosis induction by Semliki Forest virus (SFV) and its derived vector for tumor treatment, we have utilized the poorly immunogenic and rapidly growing K-BALB and CT26 murine tumor models," researchers in Ireland say.

"Both cell lines underwent apoptosis and expressed viral antigen when infected with the SFV4 strain of SFV, or recombinant SFV (rSFV) virus-like particles (VLPs) encoding the p62-6k viral structural proteins. VLPs were used to immunize groups of BALB/c and BALB/c nu/nu mice prior to subcutaneous tumor...

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