Johns Hopkins University
Akt activation can promote resistance to microtubule-directed agents
Published in Medicine and Law Weekly, March 18th, 2005
"Chemotherapeutic agents induce apoptosis in cancer cells through effects on multiple intracellular targets," oncologists in the United States explained. "Recent observations suggest that a consistent cellular response to chemotherapeutic agents of disparate classes is downregulation of glycolytic metabolism."
"Inhibition of glycolytic activity has been linked to apoptotic induction in several models," noted D.J. VanderWeele and colleagues at Johns Hopkins University. "The serine/threonine kinase Akt (protein kinase B) promotes both glycolytic metabolism and...
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