Published in Medicine and Law Weekly, April 8th, 2005
According to a study from Brazil, "The role of B7/CD28 costimulatory pathway in the polyclonal and specific lymphocyte activation induced by blood stages of Plasmodium chabaudi AS was investigated in CD28 gene knockout (CD28-/-) and C57BL/6 (CD28+/+) mice. Analysis of the spleen during the acute infection revealed a similar increase in T and B cell populations in both groups of mice. Moreover, CD28-/- mice were able to develop a polyclonal IgM response to P. chabaudi. On the contrary, the polyclonal IgG2a response...
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