Published in Medicine and Law Weekly, April 8th, 2005
"CXCR4 is one of two physiologically relevant human immunodeficiency type 1 (HIV-1) entry co-receptors. Studies of CXCR4 mutants have not clearly identified the determinants of co-receptor function and specificity. We therefore used a panel of monoclonal antibodies to further elucidate CXCR4 expression, structure, and function," researchers in the United States report.
"Our findings show the existence of conformational subpopulations of CXCR4 that are in equilibrium on the cell surface but...
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