U.S. National Cancer Institute

Cooperative effect of p12, CA during early events of MLV replication is possible

Published in Medicine and Law Weekly, June 17th, 2005

Research suggests possible cooperative effect of p12 and capsid (CA) during the early events of murine leukemia virus (MLV) replication.

"The Gag polyprotein of murine leukemia virus is processed into matrix, p12, capsid, and nucleocapsid proteins. p12 affects early events of virus replication and contains a PPPY motif important for virus release. To probe the functions of p12 in the early steps of MLV replication, we tested whether p12 can be replaced by spleen necrosis virus (SNV) p18, human immunodeficiency virus type 1 p6, or Rous sarcoma virus p2b," scientists in the United States reported.

"Analyses revealed that all chimeras generated virions...

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Source: Medicine and Law Weekly (2005-06-17)

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