Purdue University

Adenylate cyclase examined, nature of potentiation clarified

Published in Medicine and Law Weekly, June 17th, 2005

A study from the United States has reported on G alpha_q potentiation of adenylate cyclase (EC 4.6.1.1) type 9 (AC9) activity through a Ca²⁺/calmodulin-dependent pathway.

"AC9 activity has been shown to be inhibited by PMA activation of novel protein kinase C (nPKC) isoforms. In the current study the effect on AC9 activity of activating PKC in physiological relevant manner was examined," wrote M.G. Cumbay and colleagues, Purdue University.

"Contrary to the anticipated inhibitory effect of activating PKCs through G_q -coupled receptors, activation of transiently expressed G-coupled serotonin 5-HT2A or muscarinic M-5...

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Source: Medicine and Law Weekly (2005-06-17)

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