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University of Kansas

Adaptor protein Gads examined, B cell expression and function clarified

Published in Medicine and Law Weekly, June 17th, 2005

A study from the United States has reported on the expression and function of the adaptor protein Gads in murine B cells.

"Nearly all hematopoietic receptors are dependent on adaptor proteins for the activation of downstream signaling pathways. The Gads adaptor protein is expressed in many hematopoietic tissues, including bone marrow, lymph node, and spleen.

"Using intracellular staining, we detected Gads protein in a number of cells, including B cells, T cells, NK cells, monocytes, and plasmacytoid DC, but not in macrophages, neutrophils, or monocyte-derived DC," wrote T.M. Yankee and colleagues, University of Kansas.

"In the B...

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