University of Hamburg

Prion protein examined, nature of neuronal receptor recruitment clarified

Published in Medicine and Law Weekly, June 24th, 2005

According to recent research from Germany, prion protein (PrP) recruits its neuronal receptor neural cell adhesion molecule (NCAM) to lipid rafts to activate p59(Fyn) and to enhance neurite outgrowth.

"In spite of advances in understanding the role of the cellular PrP in neural cell interactions, the mechanisms of PrP function remain poorly characterized. We show that PrP interacts directly with the NCAM and associates with NCAM at the neuronal cell surface," wrote A. Santuccione and colleagues, University Hamburg.

"Both cis and trans interactions between NCAM at the neuronal surface and PrP promote recruitment of NCAM to lipid rafts and thereby...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Medicine and Law Weekly

Source: Medicine and Law Weekly (2005-06-24)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry