Medical University of South Carolina

Findings define role for MMP-3 in radiofrequency scar expansion

Published in Medicine and Law Weekly, September 23rd, 2005

A recent report describes time-dependent changes in myocardial structure following discrete injury in mice deficient of matrix metalloproteinase-3.

"Myocardial scars from radiofrequency (RF) ablation can increase in size in the postinjury period, resulting in remodeling of the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) contribute to adverse myocardial remodeling following injury. However, the role of specific MMP types in RF scar enlargement remains unclear," scientists in the United States report.

R. Mukherjee and colleagues of the Medical University of South Carolina wrote, "One MMP type, MMP-3, degrades a wide range of ECM...

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Source: Medicine and Law Weekly (2005-09-23)

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