University of Michigan

Cytochrome analyzed, functional role of highly conserved residues defined

Published in Medicine and Law Weekly, October 14th, 2005

According to a study from the United States, the highly conserved Glu-149 and Tyr-190 residues contribute to peroxynitrite (PN)-mediated nitrotyrosine formation and the catalytic activity of cytochrome P4502B1.

"Tyr-190 in cytochrome P450 2131 has previously been shown to be a prime target for nitration by PN resulting in nitrotyrosine formation and the inactivation of this enzyme. Modeling studies have suggested that Tyr-190 may play a structural role in maintaining the integrity of the protein for maximal activity through hydrogen bonding with Glu-149," wrote H.L. Lin and colleagues, University Michigan.

"To elucidate the roles of Tyr-190 and...

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Source: Medicine and Law Weekly (2005-10-14)

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