Published in Medicine and Law Weekly, October 14th, 2005
"Tyr-190 in cytochrome P450 2131 has previously been shown to be a prime target for nitration by PN resulting in nitrotyrosine formation and the inactivation of this enzyme. Modeling studies have suggested that Tyr-190 may play a structural role in maintaining the integrity of the protein for maximal activity through hydrogen bonding with Glu-149," wrote H.L. Lin and colleagues, University Michigan.
"To elucidate the roles of Tyr-190 and...
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